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Ultrasound Guidance Lowers Risks of Thoracic Nerve Block Technique for Mastectomy

Newswise — January 14, 2016 – A regional anesthesia technique called thoracic paravertebral nerve block (TPVB) is highly effective in controlling pain after breast cancer surgery, but concern about potential complications may limit its use. A new study provides evidence that using ultrasound to guide the nerve blocking procedure lowers the risk of complications, reports a study in Anesthesia & Analgesia.

In particular, ultrasound-guided nerve blocking avoids potentially serious complications related to inadvertent puncture of the tissue lining the lungs (pleura), according to the report by Dr. Peter Stefanovich and colleagues of Massachusetts General Hospital, Boston.

Ultrasound-Guided Injection Makes Nerve Blocking Safer
The researchers analyzed their experience with this nerve blocking in 856 women undergoing mastectomy from 2010 through 2013. In this procedure, a small amount of local anesthetic is injected around the thoracic nerve roots where they emerge from the spinal cord. This numbs the entire area of the chest, on one or both sides (if the nerves on both sides of the spinal cord are injected).

This regional nerve block provides excellent control of pain after breast cancer surgery. That’s especially important because pain in the immediate postoperative period is a major risk factor for the development of chronic pain in women who have undergone mastectomy.

However, this nerve blocking isn’t performed as often as it might be because of patient safety concerns—especially the risk of puncturing the pleura due to incorrect needle placement. This can lead to a serious complication called pneumothorax, where air enters the chest cavity, potentially causing collapse of the lung.

Dr. Stefanovich and colleagues analyzed their experience with ultrasound guidance to make this nerve blocking safer. Using ultrasound, the anesthesiologists performing nerve blocking were able to visualize the exact location of the thoracic spinal nerve roots. Ultrasound was used in addition to the conventional approach, using anatomical landmarks to guide the injection.

Following this procedure, anesthesiologists were able to confirm correct needle placement before injecting the local anesthetic. In the experience of more than 14,000 thoracic spinal nerve injections, there were no pleural punctures and no cases of pneumothorax.

Major complications related to this nerve blocking placement developed in six patients—a rate of 0.70 percent. Four patients had drops in blood pressure and heart rate, while two had suspected toxic effects of the local anesthetic used for the procedure.

Previous reports have suggested that performing this nerve block under ultrasound guidance might make the procedure safer. The new study is the first to provide evidence that ultrasound-guided nerve blocking lowers the risks of pleural puncture and pneumothorax.

“Avoidance of these complications may be a consequence of improved safety using real-time visualization and imaging of the pleura with ultrasound,” Dr. Stefanovich and coauthors write. They hope their experience will encourage other hospitals to offer this highly effective regional anesthesia technique—potentially reducing the common and difficult-to-treat problem of chronic pain after mastectomy.

“Thoracic paravertebral nerve block is a technique that many consider to be high risk,” comments Dr. Steven L. Shafer of Stanford University, Editor-in-Chief of Anesthesia & Analgesia. “This study provides convincing evidence that, with ultrasound guidance and in experienced hands, TPVB is not a high-risk procedure.”

Anesthesia & Analgesia is published by Wolters Kluwer.

Read the article in Anesthesia & Analgesia.


About Anesthesia & Analgesia
Anesthesia & Analgesia was founded in 1922 and was issued bi-monthly until 1980, when it became a monthly publication. A&A is the leading journal for anesthesia clinicians and researchers and includes more than 500 articles annually in all areas related to anesthesia and analgesia, such as cardiovascular anesthesiology, patient safety, anesthetic pharmacology, and pain management. The journal is published on behalf of the IARS by Lippincott Williams & Wilkins (LWW), a division of Wolters Kluwer Health.

About the IARS
The International Anesthesia Research Society is a nonpolitical, not-for-profit medical society founded in 1922 to advance and support scientific research and education related to anesthesia, and to improve patient care through basic research. The IARS contributes nearly $1 million annually to fund anesthesia research; provides a forum for anesthesiology leaders to share information and ideas; maintains a worldwide membership of more than 15,000 physicians, physician residents, and others with doctoral degrees, as well as health professionals in anesthesia related practice; sponsors the SmartTots initiative in partnership with the FDA; supports the resident education initiative OpenAnesthesia; and publishes two journals, Anesthesia & Analgesia and A&A Case Reports.

About Wolters Kluwer
Wolters Kluwer is a global leader in professional information services. Professionals in the areas of legal, business, tax, accounting, finance, audit, risk, compliance and healthcare rely on Wolters Kluwer’s market leading information-enabled tools and software solutions to manage their business efficiently, deliver results to their clients, and succeed in an ever more dynamic world.

Wolters Kluwer reported 2014 annual revenues of €3.7 billion. The group serves customers in over 170 countries, and employs over 19,000 people worldwide. The company is headquartered in Alphen aan den Rijn, the Netherlands. Wolters Kluwer shares are listed on NYSE Euronext Amsterdam (WKL) and are included in the AEX and Euronext 100 indices. Wolters Kluwer has a sponsored Level 1 American Depositary Receipt program. The ADRs are traded on the over-the-counter market in the U.S. (WTKWY).

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