Using animal tissue samples–store-bought pork loin and beef liver–researchers from the University of Illinois at Urbana-Champaign have demonstrated the possibility of real-time video-rate data transmission through tissue for in-body ultrasonic communications with implanted medical devices.
“Using ultrasonic signals, we envision the ability to not only control implanted medical devices in the body but to provide live streaming of high-definition video from devices inside the body,” explained Andrew Singer, the Fox Family Professor in the Department of Electrical and Computer Engineering at Illinois. “You can imagine a device that is swallowed for the purposes of imaging the digestive tract but with the capability for the HD video to be continuously streamed live to an external screen and the orientation of the device controlled wirelessly and externally by the physician. This may seem like science fiction today, but at the root of science fiction are questions about what is possible. We wanted to show that it was possible, and engineering is about always reaching toward that adjacent possible.”
In this study–reported in a paper, “Mbps Experimental Acoustic Through-Tissue Communications: MEAT-COMMS” posted on arXiv.org–the researchers demonstrated that improved signal processing techniques can provide high data rates (>30Mbps) with low error rates through tissues at frequencies that would allow propagation through the body (<10 MHz).
“To our knowledge, this is the first time anyone has ever sent such high data rates through animal tissue,” Singer added. “These data rates are sufficient to allow real-time streaming of high definition video, enough to watch Netflix, for example, and to operate and control small devices within the body.”
To date, cardiac patients represent the largest segment of patients making use of wireless telemetry from implanted medical devices. However the number and types of applications are increasing rapidly for implanted pacemakers and defibrillators, glucose monitors and insulin pumps, intracranial pressure sensors, epilepsy control, ingestible cameras for imaging the digestive track, and many more applications.
“This work explores the use of such methods for communications through tissue for potential biomedical applications, using the tremendous bandwidth available in commercial medical ultrasound transducers,” said Michael Oelze, associate professor of electrical and computer engineering at Illinois. “The increased demand for these devices and the opening up of new applications for implanted medical devices will continue to amplify the role of these devices for patient care and management of disease.”
For implanted medical devices, sensor transmission is characterized by low peak power and low duty cycle to reduce the potential for adverse bio-effects and to extend battery life. Other approaches seek to recharge small batteries in these devices wirelessly by converting energy from a transmitted signal from an external device (as either electromagnetic or ultrasonic wave energy) into electro-chemical storage. Therefore, the use of wave propagation for communication and interaction with implanted medical devices is an integral part of current and future device development.
Currently, most implanted medical devices use RF electromagnetic waves to communicate through the body. The Federal Communications Commission (FCC) regulates the bandwidths that can be used for RF electromagnetic wave propagation available to implanted medical devices. For example, the Medical Device Radiocommunication Service (MDRS) designates frequencies of operation ranging from 401-406 MHz. The corresponding maximum bandwidth allowed is 300 kHz, which inherently limits the communication rates of these devices, and is reported in current devices to be limited to a maximum of 50 kb/s.
“For underwater applications, radio-frequency (RF) electromagnetic communications has long since been supplanted by acoustic communication,” Singer noted. “Acoustic or ultrasonic communication is the preferred communication means underwater because sound (pressure) waves exhibit dramatically lower losses than RF and can propagate tremendous distances for signals of modest bandwidth.”
Beyond bandwidth restrictions, the main limitation for using RF electromagnetic waves in the body is loss of signal that occurs because of attenuation in the body. Losses in soft tissues are comparable to losses in salt water, which is a major constituent of soft tissues and is a high loss medium for propagation of RF electromagnetic waves. Soft tissues each have their respective high loss dielectric properties which result in scattering and multipath of signals as well as loss. In order to overcome these losses, higher power must be used and this can result in heating of tissues due to absorption.
Adverse bio-effects associated with radiation of electromagnetic waves in the body have not been studied in detail and long term biological effects of heating and non-thermal effects, such as purported increased risk of cancer or other cell damage, warrant additional study the researchers said.
“These perceived risks can be as important as the actual risks in deterring progress,” said Oelze. “These issues have impeded progress in developing intra-body wireless networks, allowing devices to communicate with each other through the body and with external devices.”
University of Illinois College of Engineering